Detailed Information On Safety The safe use and toxicology of an essential oil isn't a cut and dry subject. It is important to keep in mind that the quality of an essential oil does not determine its safety for use. Safe use is not only dependent on the toxic nature of an essential oil but also on the concentration, dosage, frequency of use, and route of administration. The dosage concentration of a substance topically, orally and otherwise makes a difference as to its therapeutic benefits and its toxic effects. It is important to keep in mind that depending on the plant, it can take anywhere from 12.5 lbs – 100 lbs of plant material to create 1 oz of essential oil; they are very concentrated substances. Also consider that frequency of application also plays a part as to the ultimate effects of using any substance. For instance, daily use of a relatively small quantity of a toxic essential oil, over a period of several months, could cause minor tissue damage to the kid...